Nigel G J Richards Selected Research

Aspartate-Ammonia Ligase (Asparagine Synthetase)

1/2019	High-resolution crystal structure of human asparagine synthetase enables analysis of inhibitor binding and selectivity.
10/2012	A sulfoximine-based inhibitor of human asparagine synthetase kills L-asparaginase-resistant leukemia cells.
4/2008	Mass spectrometric quantification of asparagine synthetase in circulating leukemia cells from acute lymphoblastic leukemia patients.
12/2006	An inhibitor of human asparagine synthetase suppresses proliferation of an L-asparaginase-resistant leukemia cell line.
8/2005	Efficient expression, purification, and characterization of C-terminally tagged, recombinant human asparagine synthetase.

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Nigel G J Richards Research Topics

Disease

4	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 01/2020 - 08/2005
4	Leukemia 10/2012 - 06/2003
3	Neoplasms (Cancer) 05/2022 - 01/2019
1	Breast Neoplasms (Breast Cancer) 01/2019
1	Obesity 01/2005
1	Hyperoxaluria (Oxaluria) 01/2005
1	Feeding and Eating Disorders (Eating Disorder) 01/2005

Drug/Important Bio-Agent (IBA)

6	Asparaginase (Elspar)FDA Link 01/2020 - 08/2005
5	AsparagineIBA 01/2020 - 01/2006
5	Aspartate-Ammonia Ligase (Asparagine Synthetase)IBA 01/2019 - 08/2005
3	EnzymesIBA 01/2020 - 01/2005
3	Pharmaceutical PreparationsIBA 01/2019 - 06/2003
1	Adenosine Triphosphate (ATP)IBA 05/2022
1	ATP-Binding Cassette Transporters (ABC Transporters)IBA 05/2022
1	Member 1 Subfamily B ATP Binding Cassette TransporterIBA 05/2022
1	Proteins (Proteins, Gene)FDA Link 04/2008
1	Agouti-Related ProteinIBA 01/2005
1	PeptoidsIBA 01/2005
1	Type 4 Melanocortin Receptor (Melanocortin-4 Receptor)IBA 01/2005
1	OxalatesIBA 01/2005
1	Peptides (Polypeptides)IBA 01/2005

Therapy/Procedure

2	Therapeutics 01/2020 - 01/2019
1	Combination Drug Therapy (Combination Chemotherapy) 01/2020